Microcirculatory Perfusion in Patients With Coma After Out-of-hospital Cardiac Arrest

Medical Centre Leeuwarden

Status: Completed

Conditions: Cardiac Arrest

Treatments: Device: microcirculation by SDF and NIRS, in 33 and 36 degrees

Study type: Observational

Funder types: Other

Identifiers

NCT01850485

TPO 745

Details and patient eligibility

About

The hypothesis is: In patients after an out of hospital cardiac arrest, treated with therapeutic hypothermia (33°C) will be found significantly more microcirculatory abnormalities, compared to the same group of patients treated with 36°C.

Full description

The purpose of this study is to investigate the (sublingual) microcirculation in patients after an out of hospital cardiac arrest (OHCA). The microcirculation is measured in this study by Sublingual Side Stream Darkfield (SDF) Imaging and Near InfraRed Spectroscopy (NIRS) at admission and after 12 and 24 hours.

Enrollment: 22 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• out-of-hospital cardiac arrest
• > 18 years
• informed consent
• ROSC (return of spontaneous circulation) < 4 hours

Exclusion criteria

• recent maxillofacial surgery
• participation in other clinical trials

Trial design

22 participants in 2 patient groups

normothermia, 36 degrees

Description:

microcirculation after cardiac arrest by SDF and NIRS, in patients treated with 36 degrees, difference is temperature, in this group 36

Treatment:

Device: microcirculation by SDF and NIRS, in 33 and 36 degrees

33 degrees, therapeutic hypothermia

Description:

microcirculation after cardiac arrest by SDF and NIRS, in patients treated with 33 degrees, difference is temperature, in this group 33

Treatment:

Device: microcirculation by SDF and NIRS, in 33 and 36 degrees