Microembolic Detection in Acute Ischemic Stroke Patients With Atrial Fibrillation and Outcome

Centro Hospitalar De São João, E.P.E.

Status: Completed

Conditions: Atrial Fibrillation; Embolism; Infarction, Brain

Treatments: Other: The presence and rate of MES measured by TCD monitoring

Study type: Observational

Funder types: Other

Identifiers

NCT06018090

362/19

Details and patient eligibility

About

This multicenter international prospective cohort study will include patients with AIS with a known or newly diagnosed anticoagulant-naïve AF. All centers will use the same transcranial Doppler machine for one-hour monitoring with bilateral 2-MHz probes within 24 hours of symptom onset. Recordings will be analyzed for MES by a blinded central reader. The primary aim is to determine the proportion of patients with MES and the association of MES with functional outcomes assessed by a modified Rankin scale (mRS) score at 90 days.

Enrollment: 61 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• acute ischemic stroke admitted to the Stroke Unit, history of AF/flutter or a new diagnosis of AF at the stroke, and with a possibility to be monitored within 24 hours after symptom onset.

Exclusion criteria

• use of anticoagulants at stroke onset; prosthetic valves; inadequate temporal bone window; uncooperative patients.

Trial design

61 participants in 1 patient group

Acute Ischemic Stroke Patients with Atrial Fibrillation

Treatment:

Other: The presence and rate of MES measured by TCD monitoring