Microflora and Metabolomics of Crohn's Disease Patients

Tongji University

Status: Unknown

Conditions: Crohn Disease

Study type: Observational

Funder types: Other

Identifiers

NCT04965584

SHSYXK

Details and patient eligibility

About

The purpose of this study is to explore the microflora characteristics of different ecological loci and multiple metabolic pathways in Crohn's disease patients with different disease course states.

Full description

This study aims to investigate the characteristics of microflora in the oral and tongue base, small intestinal stomy and lower respiratory tract, as well as the characteristics of multiple metabolic pathways such as bile acid metabolism and amino acid metabolism in Crohn's disease patients with different course states.

Enrollment: 60 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. individuals who were clear and signed the informed consent.
2. Male and female.

Exclusion criteria

1. Any one who can not provide accurate information.
2. Any one who denies the study.

Trial design

60 participants in 3 patient groups

Active Crohn's disease group

Description:

Patients diagnosed with Crohn's disease after comprehensive evaluation of clinical symptoms, endoscopic features, radiological manifestations and histological features were recruited, and patients with CDAI score ≥ 150 were included in this group.

Crohn's disease remission group

Description:

Patients diagnosed with Crohn's disease after comprehensive evaluation of clinical symptoms, endoscopic features, radiological features and histological features were recruited, and patients with CDAI score \< 150 were included in this group.

Healthy control group

Description:

Normal healthy people were randomly recruited as the control group