Micromanaging Human Sleep Physiology to Treat Sleep Apnea and Other Disorders

Northwestern University

Status: Enrolling

Conditions: Sleep Apnea Obstructive (OSA)

Treatments: Behavioral: Wake training + TMR

Study type: Interventional

Funder types: Other

Identifiers

NCT06926036

FP00002577

Details and patient eligibility

About

This study will examine whether a combination of breathing training during wake and targeted reactivation of the training during sleep can induce breathing changes during sleep and subsequent cognitive benefits during wake.

Participants with obstructive sleep apnea (who have not yet been treated for sleep apnea) will be recruited. Participants will engage in breath training for one week in their own homes and to record their sleep at home using commercially available mobile devices and subsequently have their sleep monitored for one night of polysomnography recordings plus targeted reactivation in a laboratory setting.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

1. Right-handed, English-speaking adults, 18-60 years old who report normal hearing during sleep
2. Participants with suspected obstructive sleep apnea (OSA) (including those who have been diagnosed by a physician and those whose self-reported symptoms of OSA on the STOP-BANG questionnaire classify them as being "individuals with intermediate to high risk".
3. No report of any other sleep disorder besides OSA.
4. No report of any neurological or cardiometabolic diseases or disorders.
5. Not currently under active treatment for sleep apnea.
6. BMI ≤ 40.

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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50 participants in 1 patient group

All participants

Experimental group

Treatment:

Behavioral: Wake training + TMR