Micrometastases in Axillary Lymph Nodes in Breast Cancer, Post-neoadjuvant Chemotherapy

Yonsei University Health System (YUHS)

Status: Completed

Conditions: Micrometastases; Neoadjuvant Chemotherapy

Treatments: Procedure: Sentinel lymph node biopsy, axillary lymph node dissection

Study type: Observational

Funder types: Other

Identifiers

NCT06149884

3-2023-0214

Details and patient eligibility

About

This study aims to investigate the significance of minimal residual axillary disease following NAC, with a particular focus on micrometastases (ypNmi), in comparison to pathologic lymph node-negative (ypN0) or macrometastases (ypN+). The investigators will further explore the prognostic implications of SLNmi for the prediction of axillary LN status and survival outcomes.

Full description

This study aims to investigate the significance of minimal residual axillary disease following NAC, with a particular focus on micrometastases (ypNmi), in comparison to pathologic lymph node-negative (ypN0) or macrometastases (ypN+). The investigators will further explore the prognostic implications of SLNmi for the prediction of axillary LN status and survival outcomes.

Enrollment: 978 patients

Sex: Female

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Stage II or III primary breast cancer patients
• Patients who performed neoadjuvant chemotherpay
• Patients who underwent axillary lymph node dissection with or without sentinel lymph node biopsy

Exclusion criteria

• Patients who performed upfront surgery
• De novo stage IV patients