Microneedling Alone vs Microneedling With PRP in the Treatment of Macular Amyloidosis; a Split Face Comparative Study

Cairo University (CU)

Status: Not yet enrolling

Conditions: Macular Amyloidosis

Treatments: Device: microneedling with PRP; Device: microneedling

Study type: Interventional

Funder types: Other

Identifiers

NCT07360860

MS-59-2025

Details and patient eligibility

About

This study is going to asses and compare the efficacy of treatment of macular amyloidosis using microneedling vs PRP with microneedling. Pruritus and pigmentation will be assessed.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: • Both genders were included.

• Patients above 18 years old.
• Patients diagnosed by macular amyloidosis, proved by dermoscopy and histopathology.

Exclusion Criteria: • Prior use of topical therapies in the previous 4 weeks.

• Prior use of any procedures such as chemical peel or laser treatment in the previous 1 month.
• Prior use of any systemic treatment for macular amyloidosis in the past 12 weeks.
• Patients with other skin conditions (e.g., psoriasis, eczema).
• Immunocompromised patients (HIV, chemotherapy).
• Patients with history of any type of autoimmune disorders, coagulopathies, and keloid tendency.
• Known or suspected allergy to ingredients

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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30 participants in 2 patient groups

microneedling

Active Comparator group

Description:

microneedling will be done on the first arm

Treatment:

Device: microneedling

macular amyloidosis treated with microneedling and PRP

Active Comparator group

Treatment:

Device: microneedling with PRP