Microneedling and Latanoprost in Acrofacial Vitiligo

Sohag University

Status and phase: Unknown; Phase 3; Phase 2

Conditions: Vitiligo

Treatments: Drug: Latanoprost; Device: Microneedling

Study type: Interventional

Funder types: Other

Identifiers

NCT03611348

VIT.LT2018

Details and patient eligibility

About

To compare efficacy of topical latanoprost preceded by microneedling versus topical latanoprost alone in treatment of acrofacial vitiligo.

Full description

patients meeting inclusion and exclusion criteria presented to Dermatology Outpatient Clinic, Sohag University Hospital will be enrolled in the study after obtaining a written consent from them. Full history will be obtained and meticulous examination will be carried out. Patients will be randomly divided into 2 groups, one group will receive topical latanoprost with microneedling, and the other one will receive topical latabnoprost alone.

Enrollment: 70 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Acrofacial stable vitiligo for 6 months duration (without new lesions appearance or change in size of the existing lesions).

Exclusion criteria

• History of scar formation.
• Patients with systemic diseases (diabetes, bleeding disorders, chronic renal diseases, chronic liver diseases, asthma and hypertension).
• Patients who are receiving chemotherapy or radiotherapy.
• Pregnant and lactating females.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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70 participants in 2 patient groups

Microneedling + latanoprost

Active Comparator group

Description:

patient will receive topical application of latanoprost 0.005% eye drops solution twice daily for 3 months preceded by microneeding in sessions by dermapen every 2 weeks for 3 months (totally 6 sessions).

Treatment:

Drug: Latanoprost

Device: Microneedling

latanoprost

Active Comparator group

Description:

Patient will receive topical application of latanoprost 0.005% eye drops solution only twice daily for 3 months (active control side).

Treatment:

Drug: Latanoprost