Micronutrient Status Involved in Immunity in Elderly Patients With COVID-19 (MicroCovAging)

Civil Hospices of Lyon

Status: Completed

Conditions: Covid19

Treatments: Biological: Selenium, Zinc and Copper, Vitamin A, D, E plasma concentrations during patient hospitalization

Study type: Observational

Funder types: Other

Identifiers

NCT04877509

69HCL20_0730 A067

Details and patient eligibility

About

During the ongoing COVID-19 pandemic, age was clearly the major factor of mortality. Increasing age was strongly associated with this risk, with the upper 80 years age group having more than 12-fold increased risk compared with those aged 50-59 years. Male gender was also associated with a doubling of risk.

The elderly subject is particularly exposed to global denutrition with risk of micronutrients deficiencies such as vitamins and trace elements. Those deficits expose to lower immunity. In addition, viral infection as COVID-19 can also worsen these deficits.

In general, low levels or intakes of micronutrients such as Zn, Se and vitamin A have been associated with adverse clinical outcomes during viral infections. This notion has been confirmed in a recent review proposing that besides vitamins A and D also B vitamins, vitamin C, omega-3 polyunsaturated fatty acids, as well as selenium, zinc and iron should be considered in the assessment of micronutrients in COVID-19 patients.

In this context, the MicroCovAging study will evaluate copper, zinc and selenium, vitamin A, D and E status in elderly subjects affected by COVID- 19 and to correlate this status with prognosis of this disease.

Enrollment: 229 patients

Sex: All

Ages: 50+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Hospitalized adult patient ≥ 50 years at the time of admission,
• Suffering from confirmed COVID-19 (positive quantitative PCR for SARS-CoV-2 and/or chest scanner suggestive of COVID-19),
• Informed and non-opposed to the research. Patient will be informed of the study by his medical doctor during hospitalization or by post thanks to a generic information sheet dedicated to COVID-19 researches.

Exclusion criteria

• Adult patient < 50 years at the time of admission
• Negative quantitative PCR for SARS-Cov-2

Trial design

229 participants in 1 patient group

Over 50 year's COVID-19 patients hospitalized at HCL from 1st March to 29th May 2020.

Treatment:

Biological: Selenium, Zinc and Copper, Vitamin A, D, E plasma concentrations during patient hospitalization