Microparticles Circulating Plasma Concentration in Atrial Fibrillation After Percutaneous Occluding of the Left Atrium (MICROPLUG)

Institut Mutualiste Montsouris

Status: Unknown

Conditions: Atrial Fibrillation

Treatments: Other: blood sampling

Study type: Observational

Funder types: Other

Identifiers

NCT03361202

CARDIO-01-2015

Details and patient eligibility

About

The aim of the study is to compare levels of differnts types of microparticles circulating before and after percutaneous occluding of the left atrium by patients with atrial fibrillation and patients control.

Hypothesis is that prothesis implantation will decrease levels of microparticles circulating in blood circulation because of occluding of the left atrium .

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

atrial fibrillation group:

• high embolic risk (CHADS-VASC2 score ≥4)
• formal and final contraindication to anticoagulant therapy
• no heart thrombus on ETO and TDM before percuraneous occluding

control group:

• suspicion of stable coronary artery disease, coronary angiography scheduled and double platelet aggregation (clopidogrel and aspirine)

Exclusion Criteria: for both groups

• congestive heart failure, severe aortic stenosis, EP or TVP early.

Trial design

50 participants in 2 patient groups

Atrial fibrillation group

Description:

blood sampling

Treatment:

Other: blood sampling

control group

Description:

blood sampling

Treatment:

Other: blood sampling