Microplastics in Paraneoplastic and Intratumoral for Colorectal Cancer

Dong Peng

Status: Active, not recruiting

Conditions: Microplastic Exposure; Colorectal Cancer (MSI-H)

Treatments: Other: exposure to microplastic

Study type: Observational

Funder types: Other

Identifiers

NCT07063550

2024-531-01

Details and patient eligibility

About

The objective of this study is to identify and characterize microplastics present in peritumoral and intratumoral tissues of colorectal cancer patients, and to investigate their associations with gut microbiome composition and metabolic profiles. By integrating microplastic analysis with metagenomic and metabolomic data, we aim to explore the potential impact of environmental microplastic exposure on tumor microenvironment alterations, microbial dysbiosis, and metabolic reprogramming in colorectal cancer.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients (≥18 years old) with histologically confirmed colorectal adenocarcinoma.
• Undergoing elective radical colorectal cancer resection at the study hospital.
• No prior chemotherapy, radiotherapy, or targeted therapy before surgery.
• Availability of both tumor tissue and adjacent normal (peritumoral) tissue samples during surgery.
• Willingness to provide stool and/or blood samples for metagenomic and metabolomic analysis.
• Ability to understand the study procedures and provide written informed consent.

Exclusion criteria

• Patients with a history of other malignancies within the past 5 years.
• Emergency surgery due to obstruction, perforation, or bleeding.
• Inadequate sample quality or volume for microplastic, metagenomic, or metabolomic analysis.
• Presence of chronic inflammatory bowel disease (e.g., Crohn's disease or ulcerative colitis).
• Use of antibiotics, probiotics, or prebiotics within 4 weeks prior to sample collection.
• Pregnant or breastfeeding women.
• Refusal or inability to provide informed consent.

Trial design

100 participants in 1 patient group

the colorectal cancer group

Description:

patients diagnosed with colorectal cancer

Treatment:

Other: exposure to microplastic