Micropulse Diode Laser Treatment for Chronic Central Serous Chorioretinopathy

Federal University of São Paulo

Status: Completed

Conditions: Central Serous Chorioretinopathy

Treatments: Procedure: Subthreshold diode micropulse laser

Study type: Interventional

Funder types: Other

Identifiers

NCT01327170

SDMCCSC-FM

Details and patient eligibility

About

The aim of this study was to evaluate safety and therapeutic response to micropulse diode 810nm laser treatment in patients with chronic central serous chorioretinopathy.

Full description

Most of the cases of central serous chorioretinopathy (CSC) recur spontaneously within three months of disease. After 3 months without resolution of acute CSC or in chronic CSC, continuous wave laser photocoagulation or photodynamic therapy should be considered. Direct threshold continuous photocoagulation treatment can shorten the duration of the serous detachment, but it is not appropriate for juxtafoveal or subfoveal leakage point.Subvisible photocoagulation potentially localizes and decreases chorioretinal thermic burn. Subthreshold diode micropulse (SDM) laser using a 810nm diode laser may spare the damage to the neural retina by raising the temperature of the RPE to just below the protein-denaturation threshold so that the thermal wave that reaches the neural retina is insufficient to cause neither damage nor clinically visible end-point. This therapeutic laser modality offers the possibility to minimize the iatrogenic retinal lesion.

Enrollment: 15 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Chronic active central serous chorioretinopathy lasting more than 6 months
• Leakage at fluorescein angiogram

Exclusion criteria

• Opacities of the clear refractive media of the eye
• Any intraocular surgery within the 6 months prior to study entry
• Prior vitrectomy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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15 participants in 2 patient groups

Subthreshold diode micropulse laser

Active Comparator group

Description:

Subthreshold diode micropulse laser in patients with chronic central serous chorioretinopathy

Treatment:

Procedure: Subthreshold diode micropulse laser

Sham

Sham Comparator group

Description:

Sham group simulating the laser treatment

Treatment:

Procedure: Subthreshold diode micropulse laser