MicroPulse Transscleral Laser Therapy and Its Short-term Impact on Ocular Surface

University Tunis El Manar

Status

Completed

Conditions

Conjunctiva

Cornea

Treatments

Procedure: conjunctival biopsy after micropulse transscleral laser therapy

Study type

Interventional

Funder types

Other

Identifiers

NCT06353776

02052023

Details and patient eligibility

About

MicroPulse transscleral laser therapy (TLT) is proven to be effective in reducing intraocular pressure with minimal complications in either primary or secondary glaucoma. However, its impact on the human ocular surface remains unexplored. This study aims to bridge this gap by examining the clinical and histopathological effects of MicroPulse TLT on the ocular surface.

Full description

This prospective study, conducted at Mohamed Taher Maamouri University Hospital in Nabeul, Tunisia, investigates the clinical and histopathological short-term effects of MicroPulse transscleral laser therapy (TLT) on the ocular surface. The study involves 16 eyes from 15 adult patients. Participants underwent MicroPulse TLT, followed by conjunctival biopsies for the analysis of inflammation and fibrosis. Participants also benefited from ophthalmological examination and responded to the Ocular Surface Disease Index (OSDI) questionnaire before and after MicroPulse TLT.

Enrollment

15 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age > 18 years old
Non-controlled open-angle glaucoma despite undergoing maximal medical therapy
Poor therapeutic adherence
Local or general intolerance to topical treatments.

Exclusion criteria

Ophthalmic or general diseases that could potentially impact the conjunctiva such as symblepharon, ocular injury, or prior eye surgery
Pevious transscleral laser therapy applied to the same eye
angle-closure glaucoma
active ocular inflammation
a non-functional eye (absence of light perception)
scleral thinning