MicroRNAs in Acute Kidney Injury (MIRAKI)

Heinrich-Heine University, Duesseldorf

Status: Completed

Conditions: Kidney Injury in Cardiac Surgery - Expression of microRNAs

Treatments: Other: observation of microRNA expression

Study type: Observational

Funder types: Other

Identifiers

NCT03089242

2017024132

Details and patient eligibility

About

Profiling of microRNAs and long noncoding RNAs (lncRNAs) in patients undergoing cardiac surgery. Analysis: Prediction of acute kidney injury by plasma expression profile of microRNAs?

Full description

In this pilot study we will include 150 patients undergoing cardiac surgery in a German university hospital. We will profile microRNA expression in plasma and urine before and at several timepoints after surgery. We will use a preselected panel of microRNAs and lncRNAs for analysis. Goal is to identify microRNAs/lncRNAs that are able to predict the occurence of AKI in these patients.

Enrollment: 150 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• cardiac surgery

Exclusion criteria

• preexisting chronic kidney injury
• inclusion in another study
• pregnancy
• Kidney transplantation in history
• GFR < 30 ml/min (glomerular filtration rate)
• ECLS therapy (extracorporal life support)