Microtransplantation in Older Patients With Acute Myeloid Leukemia

The Affiliated Hospital of the Chinese Academy of Military Medical Sciences

Status and phase: Completed; Phase 2

Conditions: Acute Myeloid Leukemia

Treatments: Biological: microtransplantation

Study type: Interventional

Funder types: Other

Identifiers

NCT02831192

EAML-MST

Details and patient eligibility

About

The purpose of this study is to see whether HLA-mismatched donor cells infusion with chemotherapy (microtransplantation，MST) could increase complete remission (CR) and improve survival in older patients with acute myeloid leukemia (AML)，the investigators conducted a prospective, multicenter clinical trial of HLA-mismatched MST to estimate outcomes and toxicities.

Enrollment: 150 patients

Sex: All

Ages: 60 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• de novo acute myeloid leukemia
• age 60-90
• have HLA mismatched donor

Exclusion criteria

• have no suitable donor or donor refused
• patient refused to accept donor cells

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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150 participants in 1 patient group

MST（microtransplantation）

Experimental group

Treatment:

Biological: microtransplantation