Microvascular Profiling of Nodules in the Thyroid Gland

Rigshospitalet

Status

Enrolling

Conditions

Thyroid Nodular Disease

Study type

Observational

Funder types

Other

Identifiers

NCT07041307

SURE-THYROID

Details and patient eligibility

About

The purpose of this study is to examine tiny blood vessels in different thyroid nodules using advanced ultrasound. In the long term, we hope this can help doctors better tell the difference between types of nodules and more accurately decide who may need surgery.

Full description

In this study, the investigators use an advanced ultrasound technique called Super-Resolution Ultrasound of Erythrocytes (SURE) to map the microvasculature in the thyroid gland and thyroid nodules. This method provides much higher resolution than conventional ultrasound, allowing us to visualize and measure even the smallest blood vessels.

The investigators aim to explore whether this technique can help differentiate between various types of thyroid nodules - including benign and malignant - and possibly between hyper-, iso-, and hypofunctioning nodules, based on their microvascular characteristics.

Enrollment

50 estimated patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age over 18 years
Written and verbal informed consent to participate in the study
Patients with hypo-, iso-, or hyperfunctioning thyroid nodules
Patients referred for thyroid surgery due to suspected malignant nodule (including Bethesda classification groups III, IV, V, and VI)
Healthy volunteers - generally good health with no chronic illnesses

Exclusion criteria

Pregnancy
Inability to undergo the examination due to physical or mental limitations
Desire to opt out of receiving information about new, significant health findings revealed during the study
Healthy Participants:
Thyroid disease, including nodules, as well as current or past conditions affecting the thyroid
Medication that affects thyroid function