Midazolam Versus Dexamethasone as an Adjuvant to Local Anesthetics in the Ultrasound Guided Hydrodissection of Median Nerve for Treatment of Carpal Tunnel Syndrome Patients

Minia University

Status

Completed

Conditions

Pain Syndrome

Treatments

Drug: Dexamethasone

Drug: Midazolam injection

Study type

Interventional

Funder types

Other

Identifiers

NCT04527770

644/4-2020

Details and patient eligibility

About

midazolam and dexamethasone both can counteract chronic pain. either via GABA mimetic action or via anti prostaglandins

Full description

Entrapement syndrome - namely median nerve compression in carpal tunnel syndrome - causes chronic pain that can be refractory to medical treatment . Ultrasound guided hydrodissection is an option for alleviating pain . Recurrence is the main side effect of injection. We try in this research to prevent recurrence rate . Midazolam and dexamethasone both are used in chronic pain . Midazolm act by GABA mimetic action while dexamethasone act by decrease interleukin formation

Enrollment

134 patients

Sex

All

Ages

30 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

numbness or pain in the nerve distribution, nerve conduction studies (NCS) corresponding with AANEM guidelines
Nerve cross sectional area >12mm2

Exclusion criteria

Refusal to participate
History of operation in median nerve.were patient refusal to participate, pain recurrence after previous injection and severe symptoms requiring surgical release, diabetic patients