Midkine Role With Deregulated Oxidative and Immune Milieu in Induction of Preeclampsia

Benha University

Status: Completed

Conditions: Pre-Eclampsia

Treatments: Diagnostic Test: ELISA

Study type: Interventional

Funder types: Other

Identifiers

NCT06329284

RC 31.1.2024

Details and patient eligibility

About

Preeclampsia (PE) is a hypertensive pregnancy-related disorder that endangers maternal and fetal outcomes and accounts for 9-10% of maternal mortalities with its early-onset phenotype is the most dangerous, but its etiology is still not fully elucidated.

Midkine (MDK) is a multifunctional protein that plays a unique role in the development of hypertension (HTN), via its proatherogenic effect and induction of overexpression of angiotensin converting enzyme. Oxidative stress (OS) upregulates the expression of MDK and MDK induces propagation of neoangiogenesis and acts as chemotactic for neutrophils.

Enrollment: 80 patients

Sex: Female

Ages: 21 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Newly pregnant normotensive (NT) women with singleton fetus;
• Free of the Exclusion Criteria.

Exclusion criteria

• Women with history of complicated pregnancy;
• Had manifest essential hypertension, Diabetes Mellitus or chronic kidney diseases;
• Had multiple gestational sacs, morbid obesity with Body Mass Index at time of pregnancy diagnosis over 35 kg/m2;
• Had genetic disorders, coagulopathy, autoimmune diseases or maintained on immunosuppressive therapy.

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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80 participants in 1 patient group

Serum Midkine

Other group

Treatment:

Diagnostic Test: ELISA