Midodrine is Effective in Management of Intradialytic Hypotension Among Critically-ill Patients With Acute Kidney Injury

Benha University

Status: Completed

Conditions: Acute Kidney Injury

Treatments: Drug: Placebo; Drug: midodrine

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT03431194

BN-14716

Details and patient eligibility

About

The aim of this randomized trial was to assess the efficacy of oral midodrine tablets for the management of intradialytic hypotension among critically ill patients with acute kidney injury.

Full description

In This open -label study, patients in ICU with acute kidney injury are randomized to either midodrine tablets or placebo. the number of intradialytic episodes and both systolic and diastolic blood pressure between both groups are compared. Mortality and adverse effects are monitored and compared as well.

Enrollment: 80 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ICU patients
• acute kidney injury
• age above 18 years
• documented hypotension during dialysis

Exclusion criteria

• packed red blood cells transfusion
• intravenous inotropes
• alteration of blood pressure medications

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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80 participants in 2 patient groups, including a placebo group

midodrine group

Active Comparator group

Description:

Patients will receive midodrine tablets

Treatment:

Drug: midodrine

placebo group

Placebo Comparator group

Description:

Patients receive sugary oral tablets therapy

Treatment:

Drug: Placebo