Mifepristone and Misoprostol Compared With Misoprostol Alone for Second Trimester Abortion

Rambam Health Care Campus

Status and phase: Unknown; Phase 4

Conditions: Second Trimester Abortion

Treatments: Drug: Mifepristone; Drug: Placebo; Drug: Misoprostol

Study type: Interventional

Funder types: Other

Identifiers

NCT03044093

0299-16-RMB

Details and patient eligibility

About

Mifepristone and Misoprostol Compared With Misoprostol Alone for Second Trimester Abortion - a Double Blinded Randomized Controlled Trial

Enrollment: 200 estimated patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy
• no allergy known to these drugs
• second trimester abortion

Exclusion criteria

• hematology diseases
• clotting factor deficiency

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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200 participants in 2 patient groups

MISOPROSTOL alone

Active Comparator group

Description:

the common practice currently in our medical center for second trimester medical abortion/ Placebo

Treatment:

Drug: Misoprostol

Drug: Placebo

Mifepristone and Misoprostol

Experimental group

Description:

in addition to the common practice currently in our medical center for second trimester medical abortion we will add Mifepristone before administering Misoprostol. Mifepristone

Treatment:

Drug: Misoprostol

Drug: Mifepristone