Mild Cognitive Impairment, Use of qEEG as a Prognostic Marker

Jon Snaedal

Status: Unknown

Conditions: Mild Cognitive Impairment

Treatments: Diagnostic Test: EEG with SPR analysis

Study type: Observational

Funder types: Other

Identifiers

NCT03659643

NORD-MCI

Details and patient eligibility

About

Multi center study of six Memory Clinics in four Nordic countries in validating a prognostic diagnostic investigation of qEEG in Mild Cognitive Impairment (MCI). The study is in two parts, the first one is a follow up of a previous study conducted in 2011-2013 and the second half is new recruitment with two years follow up. End points are diagnosis of a dementing disorder, primarily dementia of Alzheimer´s type.

Full description

The Nordic Network in Dementia Diagnostics (NIDD) conducted a study in 2011-2013 on qEEG using a method of Statistical Pattern Recognition (SPR) in six academic Memory Clinics in four Nordic countries. In the current study, those from the former study diagnosed either with Mild Cognitive Impairment (MCI; n= 120) or with Subjective Cognitive Impairment (SCI; n=60) are contacted again and evaluated for cognitive impairment. The EEG registered at entry in the former study is considered in relation to their current diagnosis (SCI,MCI or dementia) and thereby, the prognostic value of the method is evaluated.

In the second part of the study (n=120), new patients evaluated in the Memory Clinics and diagnosed with MCI (not SCI) are invited to participate for a two year follow up.

In the diagnostic work-up, simple screening tests and information from a close relative form the basis of the cognitive status (SCI;MCI, Dementia). In evaluating the cause of cognitive impairment, detailed neuropsychological testing is performed as well as MRI of the brain and CSF for Alzheimer´s markers. qEEG with SPR analysis is registered but the clinician is blinded to its outcome.

The end point in both parts of the study is a diagnosis of a dementing disorder.

Enrollment: 300 estimated patients

Sex: All

Ages: 50 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Group 1: Individuals diagnosed with either SCI or MCI during 2011-2013 Group 2: Individuals diagnosed with MCI at entry of the study

Exclusion criteria

• Age <50 years or >85 years
• Medically or psychologically unstable
• Living outside the capital region

Trial design

300 participants in 2 patient groups

Retrospective MCI cohort

Description:

EEG with SPR analysis of the group from the study 2011-2013 is evaluated in relation to the status of current cognitive impairment

Treatment:

Diagnostic Test: EEG with SPR analysis

Prospective MCI cohort

Description:

New individuals diagnosed with MCI. EEG with SPR analysis is performed during the diagnostic work-up and evaluated in relation to changes in cognitive status during the following two years.

Treatment:

Diagnostic Test: EEG with SPR analysis