MIld to MOderate Acute Pancreatitis: Early naSogastric Tube Feeding Compared With pAncreas Rest (MIMOSA)

University of Auckland, New Zealand

Status and phase: Completed; Phase 3; Phase 2

Conditions: Acute Pancreatitis

Treatments: Procedure: Enteral tube feeding

Study type: Interventional

Funder types: Other

Identifiers

NCT01128478

NTX/08/11/107

Details and patient eligibility

About

Pain relapse during oral refeeding occurs in at least one-fifth of patients with acute pancreatitis. The study hypothesis is that early administered enteral tube feeding might reduce a risk of pain relapse and shorten the length of hospital stay in patients with acute pancreatitis.

Enrollment: 35 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diagnosis of acute pancreatitis
• age 18 years or older
• written informed consent

Exclusion criteria

• > 96 hours after onset of symptoms
• > 24 hours after hospital admission
• organ failure by the time of randomization
• infectious complications before randomization
• received artificial nutrition before randomization
• previously enrolled into the trial
• chronic pancreatitis
• post-ERCP pancreatitis
• intraoperative diagnosis of acute pancreatitis
• pregnancy
• malignancy

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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35 participants in 2 patient groups

Enteral tube feeding

Other group

Description:

Nasogastric tube feeding started within 24 h of hospital admission

Treatment:

Procedure: Enteral tube feeding

Nil-per-mouth regimen

No Intervention group

Description:

Conventional management