Mild Versus Conventional Ovarian Stimulation for Poor Responders Undergoing In Vitro Fertilisation

National and Kapodistrian University of Athens

Status and phase: Completed; Phase 2; Phase 1

Conditions: Infertility

Treatments: Procedure: mild ovarian stimulation; Procedure: conventional ovarian stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT01319708

1234561

Details and patient eligibility

About

The investigators will examine the balance between IVF success in terms of outcome parameters, using a mild ovarian stimulation protocol, opposing it to the conventional stimulation regimens in poor responders undergoing IVF.

Enrollment: 50 patients

Sex: Female

Ages: 25 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• poor responders (age>40, previous POR, abnormal OR test)
• indication for IVF
• regular cycling patients
• BMI 19-35

Exclusion criteria

• contraindication for clomiphene citrate use or to GnRH agonists antagonists
• BMI > 35

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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50 participants in 2 patient groups

mild ovarian stimulation

Experimental group

Description:

100 mg CC by day 2 till 6, plus antagonist plus gonadotrophin 150-200IO until HCG triggering

Treatment:

Procedure: mild ovarian stimulation

conventional ovarian stimulation

Active Comparator group

Description:

300-450 IU of FSH starting by day 2 of menstrual cycle together with a fixed dose of GnRH antagonist starting by day 6 till egg recovery, or same doses using a GnRH agonist long protocol

Treatment:

Procedure: conventional ovarian stimulation