Milk and Milk-produce to Counteract the Loss of Muscle Mass and Function in Exercising Older Adults. (PRO)

U

Université de Sherbrooke

Status

Completed

Conditions

Sarcopenia

Treatments

Other: Resistance training

Study type

Interventional

Funder types

Other

Identifiers

NCT01883674
PLC-021742

Details and patient eligibility

About

This project evaluates the use of different types of proteins from various food sources after an exercise session, on muscle mass and physical capacity in aged sarcopenic men (who have low muscle mass). Specifically, researchers want to: Examine the efficiency of protein intake after exercise on muscle mass and physical abilities; Examine the impact of exercise and proteins on blood lipids (LDL cholesterol, HDL cholesterol, total cholesterol and triglycerides); Examine the impact of exercise and proteins on liver enzymes; Examine the impact of exercise and proteins on a hormone that controls hunger; Evaluate the program's impact on the ability of the body to produce energy. All participants are exercising (resistance training) and ingest one of the 3 different sources of proteins, immediately after training: Milk proteins (from milk beverage) Essential amino acids (added to a soya beverage) No protein (rice beverage - control group) Our hypothesis is that proteins from milk will induce a gain in muscle mass and physical function equivalent to the essential amino acids (EAA). We anticipate that both milk proteins and EAA will be both superior to control group. This would represent an interesting finding since milk is more accessible, palatable and cheaper than essential amino acids commercial mix.

Enrollment

41 patients

Sex

Male

Ages

65 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • 65-75 years
  • francophone or understanding French
  • muscle mass index < 10.75 kg/m2 (Janssen et al, 2004)
  • body mass index <30kg/m²
  • weight stable (< 2 kg) for 6 mo
  • no resistance exercise for 3 years
  • controlled blood pressure for at least 6 months

Exclusion criteria

  • major physical disability
  • medical treatment influencing metabolism
  • statin treatment
  • diagnosis or any sign of kidney disease

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Quadruple Blind

41 participants in 3 patient groups, including a placebo group

Milk proteins
Experimental group
Description:
This group will do a resistance training + milk proteins (milk beverage)
Treatment:
Other: Resistance training
Essential amino acids (add to soya bvg)
Experimental group
Description:
This group will do a resistance training + essential amino acids (added to soya beverage)
Treatment:
Other: Resistance training
No protein (control)
Placebo Comparator group
Description:
This group will do a resistance training + ingestion of the control beverage (no protein, rice beverage)
Treatment:
Other: Resistance training

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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