Mind-Body Walking Exercise for Chronic Obstructive Pulmonary Disease

National Taiwan University

Status: Completed

Conditions: Dyspnea; Quality of Life; Chronic Obstructive Pulmonary Disease; Heart Rate Variability; Depression; Anxiety; Exercise

Treatments: Behavioral: Mind-Body Walking

Study type: Interventional

Funder types: Other

Identifiers

NCT03388489

201312004RIND

Details and patient eligibility

About

Mind-body exercise improves symptom of negative moods, dyspnea and quality of life in chronic diseases, but these improvements for chronic obstructive pulmonary disease (COPD) are unproven. This study aims to examine the effects of dyspnea, exercise capacity, heart rate variability(HRV), anxiety, depression, interoceptive awareness, quality of life(QoL) in patients with COPD across a three-month mind-body exercise program.

Full description

Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by airflow limitation, has a high prevalence of morbidity and mortality, and results in negative physical, psychological, and quality of life (QoL) impacts. Patients with COPD typically experience dyspnea, exercise intolerance, autonomic dysfunction, anxiety, depression, and poor QoL. Mind-body intervention with walking, breathing, and mindfulness is beneficial for the health of patients with COPD. However, the result of mind-body walking intervention for patients with COPD is not clear. Thus, this study will evaluate the effects of mind-body walking exercise (MBWE) on the physical psychological wellbeing and QoL of patients with COPD.

This study will be a randomized controlled trial. Data will collect from the pulmonary clinics of a medical center in northern Taiwan. The participants will recruit and randomly assign into the MBWE group or the control group. Participants in the control group will receive their usual care. Participants in the MBWE group will receive not only their usual care but also a MBWE program, consisting of walking, breathing, and mindfulness activities, for 30 min per day, 5 days per week, for 8 weeks. Data will collect at baseline and follow up on week 4 (WK 4), week 8 (WK 8), and week 12 (WK12). The primary outcome is dyspnea using modified Borg scale. The secondary outcomes are dyspnea in daily life using modified Medical Research Council (mMRC), exercise capacity using six minute walk distance (6MWD), Heart rate variability (HRV), anxiety and depression using the Hospital Anxiety and Depression scale (HADS), interoceptive awareness using the Multidimensional Assessment of Interoceptive Awareness- Chinese version (MAIA-C), QoL using COPD Assessment Tes (CAT). The independent t-test and Chi-square test were used to examine the homogeneity of the demographic characteristics of two groups. Generalized estimating equations were used to examine the data from repeated measurements.

Enrollment: 84 patients

Sex: All

Ages: 40+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1.mild to severe COPD

Exclusion criteria

1. Patients visited the emergency room or were hospitalized previous month;
2. Long-term oxygen therapy;
3. Atrial fibrillation;
4. Severe cognitive impairment;
5. Great than class II heart failure as defined by the New York Heart Association functional classification in previous six months;
6. Pacemaker were excluded;
7. Received cancer treatment
8. Participated in other exercise trials

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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84 participants in 2 patient groups

Mind-Body Walking

Experimental group

Description:

breathing, walking and meditation

Treatment:

Behavioral: Mind-Body Walking

Usual care

No Intervention group

Description:

maintain their daily activity