MIND Diet in Relation to Malnutrition and Depression in AD

Abant Izzet Baysal University

Status: Completed

Conditions: Healthy Controls Group - Age and Sex-matched; Alzheimer Disease (AD)

Study type: Observational

Funder types: Other

Identifiers

NCT07163923

AIBU-BD-NKÖ-01

Details and patient eligibility

About

The aim of this study was to examine the association between depression, malnutrition, and the Mediterranean-Dietary Approaches to Stop Hypertension Diet Intervention for Neurodegenerative Delay (MIND) diet in Alzheimer's disease patients. This study included 30 patients with Alzheimer's disease (AD) and 30 healthy controls. A questionnaire form including sociodemographic characteristics was applied to the individuals. In addition, anthropometric measurements, biochemical parameters, nutritional status (Food Frequency Questionnaire (FFQ), Mini Nutritional Assessment-Short Form (MNA-SF), Geriatric Nutritional Risk Index (GNRI) and MIND diet scores) and mental health status (Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI)).

Full description

Significant progress has been made in understanding the neurobiological basis and treatment approaches for Alzheimer's disease (AD) and depression; however, the biological link between these two disorders has not yet been fully elucidated. A deeper understanding of this relationship could contribute to the development of more effective strategies for the prevention and treatment of both conditions. In this context, lifestyle-based interventions, such as nutrition, which have been shown to support cognitive health, emerge as a potential preventive and therapeutic approach. Therefore, the aim of this study was to examine the relationship between depression, malnutrition, and the Mediterranean-Dietary Approaches to Stop Hypertension Diet Intervention for Neurodegenerative Delay (MIND) diet in individuals with AD.

Enrollment: 60 patients

Sex: All

Ages: 60+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients aged over 60 years.
• Diagnosed with Alzheimer's disease (AD) (for AD group)
• Able to communicate with themselves or their companions
• Healthy volunteers without systemic or neurological diseases (for control group)
• Matching criteria: Age, gender, smoking status, and alcohol use

Exclusion criteria

• Chronic inflammatory diseases
• Schizophrenia
• Bipolar disorder
• Amputations
• Neoplastic disorders
• End-stage liver disease
• End-stage kidney disease

Trial design

60 participants in 2 patient groups

Alzheimer's Disease Patients

Description:

Participants diagnosed with Alzheimer's disease according to established clinical criteria. Evaluated for malnutrition and depression status. No intervention was applied.

Healthy Controls

Description:

Age- and sex-matched individuals without Alzheimer's disease. Evaluated for malnutrition and depression status. No intervention was applied.