ClinicalTrials.Veeva

Menu

MIND Diet Intervention and Cognitive Performance

S

Shiraz University of Medical Sciences

Status

Completed

Conditions

Obesity

Treatments

Other: New Dietary pattern ( Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND))

Study type

Interventional

Funder types

Other

Identifiers

NCT04383704
IR.SUMS.REC.1397.759

Details and patient eligibility

About

This single-center, randomized trial examined the effect of MIND diet intervention on cognition and brain structure changes of healthy obese women over three months. The intervention group was lea to calorie-restricted modified by the MIND diet, and the control group received a calorie-restricted standard diet. The primary end-point was an assessment of cognitive performances measured with a comprehensive cognitive test battery. Secondary end-points were voxel-based morphometry to quantify the differences in brain structures. Our results revealed MIND diet could improve working memory, verbal recognition memory, and attention, more in comparison with the control group. Results also suggest that an increase in inferior frontal gyrus in the MIND diet group. Our study, for the first time, underlined that good adherence to the MIND diet as well as calorie restriction could reverse the destructive effect of obesity on cognition.

Enrollment

37 patients

Sex

Female

Ages

40 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Middle-aged women (40-60 years),
  • Without any metabolic complication,
  • BMI 30-35 kg/m2,
  • MMSE ≥ 24,
  • And no history of severe untreated medical, neurological, and psychiatric diseases which may interfere with the study intervention.

Exclusion criteria

  • Have gastrointestinal problems,
  • Participate in weight loss programs,
  • Use weight loss drugs in the last three months,
  • Had not wholly followed the dietary pattern,
  • Became pregnant,
  • And undergo special medical treatments during a three months study.

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

37 participants in 2 patient groups

calorie-restricted modified MIND diet
Experimental group
Description:
This arm received instruction in modifying the content of their diet to meet MIND pattern guidelines.
Treatment:
Other: New Dietary pattern ( Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND))
calorie-restricted standard control diet
Active Comparator group
Description:
They instructed to calorie-restricted diet alone.
Treatment:
Other: New Dietary pattern ( Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND))

Trial contacts and locations

1

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2024 Veeva Systems