Mindfulness Based Cognitive Therapy for Recurrent Depression

Radboud University Medical Center

Status: Completed

Conditions: Depressive Disorder, Major

Treatments: Behavioral: Mindfulness Based Cognitive Therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT01038765

MFN-2005-2010

2005 6028 (Other Identifier)

Details and patient eligibility

About

The purpose of this study is to investigate the effectiveness and possible mediating factors of Mindfulness Based Cognitive Therapy (MBCT) for recurrent depression.

Full description

Mindfulness Based Cognitive Therapy (MBCT) is a 8 session group intervention and is well described by several authors.

Previous studies showed Mindfulness Based Cognitive Therapy (MBCT) to be effective to prevent relapse in patients with recurrent depression and 3 or more previous depressive episodes.

Study aims are:

1. to replicate previous findings in The Netherlands, by a research team which did not develop the intervention
2. to investigate if MBCT is applicable for patients with recurrent depression and current depressive symptoms
3. to examine possible mediators of treatment effect and predictors of relapse in the year following the treatment

In this study, patients are randomly assigned to a MBCT intervention group or a waiting list control group. Patients allocated to the waiting list control condition will receive the MBCT course three months later. All patients who participated in a MBCT training will be assessed during the year following the completion of the MBCT course. We aim to include about 220 patients.

Enrollment: 220 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 3 or more previous depressive episodes
• if treated with medication: constant dose of at least 6 weeks

Exclusion criteria

• Bipolar Disorder
• Psychotic disorder
• Neurological or somatic illness affecting depression or outcome measures
• Current alcohol or drugs dependency
• Acute need of psychiatric treatment

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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220 participants in 2 patient groups

Mindfulness Based Cognitive Therapy

Experimental group

Description:

Mindfulness Based Cognitive Therapy

Treatment:

Behavioral: Mindfulness Based Cognitive Therapy

Waiting list control group

No Intervention group

Description:

3-month waiting list group