Mindfulness-based Stress Reduction (MBSR) Program Combined With Endurance Exercise Training: a Help in Treatment for Breast Cancer

University Hospital, Strasbourg, France

Status: Completed

Conditions: Breast Cancer

Treatments: Other: Mindfulness-based-stress-reduction; Other: Endurance exercise training; Genetic: Telomerase activity on a blood sample; Other: Quality of life (questionnaires); Other: Vo2max measurements; Other: Both interventions together; Other: Cerebral IRMf

Study type: Interventional

Funder types: Other

Identifiers

NCT02900326

5970

Details and patient eligibility

About

Integrative approaches to promote wellness and reduce the distress associated with cancer are considered as essential components of cancer care. In case, exercise training has been shown to produce many positive physiological and psychological benefits. Mindfulness-based stress reduction program shows similar beneficial effects, and especially in emotional distress management. The aim of the study is to examine the cumulative effect of an 8 week-exercise-training program combined with an MBSR program on cardio-respiratory fitness and quality of life in women with breast cancer. These effects are thought to be mediated in part through changes in underlying brain processes, that investigators will be put in light. Through telomerase activity, oxidative stress, mitochondrial respiration and blood cytokine level measurements, investigators could expect to better understand the effect of these combined training in breast cancer.

Enrollment: 100 patients

Sex: Female

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Breast cancer
• Having completed the chemotherapy period
• Undergoing radiotherapy and/or hormono therapy

Exclusion criteria

• Regular physical activity higher than 4 hours per week.
• Any disease cardiac, respiratory, neurological or articular disease, which counteract the muscular training )

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 4 patient groups, including a placebo group

Control patients with no intervention

Placebo Comparator group

Description:

group without intervention

Treatment:

Other: Cerebral IRMf

Other: Quality of life (questionnaires)

Other: Vo2max measurements

Genetic: Telomerase activity on a blood sample

Endurance training program (8 weeks) group

Experimental group

Description:

only physical training group

Treatment:

Other: Cerebral IRMf

Other: Quality of life (questionnaires)

Other: Vo2max measurements

Genetic: Telomerase activity on a blood sample

Other: Endurance exercise training

MBSR group (mindfulness-based-stress-reduction)

Experimental group

Description:

only mental training group (8 weeks)

Treatment:

Other: Mindfulness-based-stress-reduction

Endurance training program combined with MBSR sessions

Experimental group

Description:

Endurance training program combined with MBSR sessions, during 8 weeks (mindfulness-based-stress-reduction)

Treatment:

Other: Both interventions together