Mindfulness Intervention for People With Psychosis

The Hong Kong Polytechnic University

Status: Completed

Conditions: Recent-onset Psychosis

Treatments: Behavioral: Psychoeducation (psychosis); Behavioral: Mindfulness-based cognitive therapy (psychosis)

Study type: Interventional

Funder types: Other

Identifiers

NCT03501862

HSEARS20170811001

Details and patient eligibility

About

People with psychosis demonstrated a tendency to use maladaptive cognitive emotion regulation strategies as compared with healthy control groups.

The present study is the first randomized controlled trial of group mindfulness-based intervention for psychosis. Half group will join the mindfulness-based cognitive intervention while another half will participate in psychoeducation to examine whether mindfulness will have a positive impact on emotion regulation and distress.

Full description

Concurrently with positive and negative symptoms, affective symptoms and full affective disorder episodes are common in psychotic disorders particularly in the acute phase of illness.

Affective symptoms are a significant risk factor accounting for approximately 5-6% of suicide rates which remain or becomes higher shortly after a psychotic episode or hospital discharge (American Psychiatric Association, 2013). It has been proved that the emotion management and cognitive reappraisal were negatively associated with schizophrenia.

In the study, it is hypothesized that the intervention will have a positive impact on psychotic symptoms, general symptoms such as affective symptoms, psychological flexibility, mindfulness skills, quality of life and re-hospitalization by facilitating strategies on emotion regulation.

Enrollment: 108 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Must be Chinese residents and aged above 18
• Have a primary diagnosis of psychosis (non-affective) and/or other psychotic disorders met the Diagnostic and Statistical Manual DSM-5
• Have been diagnosed equivalent to or less than 5 years
• Mentally stable as assessed by the researcher and a psychiatrist to comprehend the education and training provided (a pre-recruitment briefing session for potential participants will be conducted to verify their ability to follow instructions and understanding in participation, and case files will be reviewed to ensure a stable medication regime for at least 6 months) in order to ensure their ability to make a valid consent
• Able to read and understand Chinese

Exclusion criteria

• Have recently participated in (less than 3 months) or are receiving other structured psycho-education and/or psychotherapies
• Have comorbidities (a) developmental impairment (b) learning disability, (c) personality disorders, and/or (d) any clinically significant medical diseases (by case-file review).
• Have organic psychosis or a primary drug or alcohol addiction

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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108 participants in 2 patient groups

Mindfulness-based intervention

Experimental group

Description:

Intervention: a twelve 1.5 weekly program on mindfulness-based cognitive therapy (psychosis)

Treatment:

Behavioral: Mindfulness-based cognitive therapy (psychosis)

Psychoeducation

Active Comparator group

Description:

Intervention: a twelve 1.5 hours weekly program on psychoeducation (psychosis)

Treatment:

Behavioral: Psychoeducation (psychosis)