Mindfulness-oriented Recovery Enhancement (MORE) for Cancer Pain Relief

Memorial Sloan Kettering Cancer Center (MSK)

Status and phase

Enrolling

Phase 2

Conditions

Cancer Pain

Chronic Pain

Treatments

Other: Standard of Care for Pain Management

Behavioral: MORE treatments

Study type

Interventional

Funder types

Other

Identifiers

NCT05877521

23-082

Details and patient eligibility

About

The purpose of this study is to evaluate whether or not mindfulness-based interventions/MBIs may help reduce chronic pain in participants who have cancer-related chronic pain. MBIs are therapeutic programs that use mindfulness meditation practices to help people focus on the present moment, as well as encourage acceptance of thoughts, emotions, and body sensations. The researchers think that an MBI treatment called Mindfulness-oriented Recovery Enhancement (MORE) may help people who are experiencing cancer-related chronic pain.

Enrollment

76 estimated patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

English speaking
Age ≥ 18 years or older
A history of cancer with no restrictions placed on type of cancer
Determined to be either no-evidence of disease or stable oncological disease by referring or study physicians/advanced practice providers
Having a pain (musculoskeletal, generalized, or neuropathic) rating of 4 or greater in worst pain on a 0-10 numerical rating scale in the preceding week
Having had pain for at least 3 months and at least 15 days with pain in the preceding 30 days
Willing to adhere to all study-related procedures, including randomization to one of two treatment arms: MORE or WLC
Ability to attend video-call session and a quiet/private location

Exclusion criteria

Active suicidality or schizophrenia
Plan to initiate palliative radiation or interventional pain procedure within the next 12 weeks
Cognitive impairment preventing completing PRO independently or participate in virtual MORE as evaluated by study clinicians

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

76 participants in 4 patient groups, including a placebo group

Wait List Control (WLC) Usual Care Procedure

Placebo Comparator group

Description:

Participants in the WLC group continue to receive their standard medical care and pain management as prescribed by their physicians or other health care providers.

Treatment:

Other: Standard of Care for Pain Management

16-hour MORE treatments

Experimental group

Description:

Patients in the 16-hour MORE format will receive one 2hrs treatment a week for 8 consecutive weeks (as per study schema: from week 1 to week 8).

Treatment:

Behavioral: MORE treatments

8-hour MORE treatments

Experimental group

Description:

Patients in the 8-hour MORE format will receive one 2hrs treatment a week for 4 consecutive weeks (as per study schema: from week 1 to week 4).