ClinicalTrials.Veeva

Menu

MINDSpeed Food and Brain Training RCT

Indiana University logo

Indiana University

Status

Completed

Conditions

Low Education
Cognitive Training
Cognition
Polyphenols

Treatments

Behavioral: Speed of processing training
Behavioral: Control foods
Behavioral: MIND foods
Behavioral: Cognitive training control

Study type

Interventional

Funder types

Other
NIH

Identifiers

NCT03419052
1703766063
R01AG052439 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The purpose of this study is to learn how foods high in polyphenols and brain training exercises affect older adults' cognitive performance

Full description

Adults with low education who give informed consent will complete a baseline cognitive assessment and then be randomized to one of four arms: 1) MIND foods and cognitive training, 2) MIND foods and control training, 3) control foods and cognitive training, or 4) control foods and control training.

All interventions are conducted through applications running on a tablet computer device that we will provide to all participants for the study duration. Cognitive training is delivered through the online BrainHQ program from Posit Science, Inc. The foods will be shown on the tablet device in an online shopping format. Selected foods will be prepared and delivered by the study team.

Active intervention will last for 12 weeks. After the 12-weeks, free food deliveries will cease but participants who were allocated to cognitive training will continue to have access to BrainHQ. Those in the MIND food arms will be encouraged to maintain MIND food consumption.

Enrollment

212 patients

Sex

All

Ages

60+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • age 60 years or older,
  • ≤ 12 years of education,
  • English speaking,
  • Marion County (and immediately surrounding counties) resident, with steady/fixed residence to receive food deliveries
  • natural-born US citizen.

Exclusion criteria

  • living in nursing home
  • self-reported diagnosis of dementia, Alzheimer's disease (AD), cancer with short life expectancy, multiple sclerosis, epilepsy, schizophrenia, bipolar disorder, Parkinson disease; current chemotherapy or radiation therapy; history of brain tumor, brain surgery, brain infection; stroke or myocardial infarction within the past 12 months
  • current alcohol consumption ≥8 drinks per week for women or ≥15 drinks per week for men;
  • poor vision (self-reported difficulty reading a newspaper) or color blind;
  • low communicative ability (examiner rated) that would interfere with interventions and assessments;
  • prior involvement in similar cognitive training studies;
  • unable or unwilling to provide blood sample at Baseline
  • tumor, hemorrhage, aneurysm, hydrocephalus, or other significant clinical finding from Baseline brain MRI

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Factorial Assignment

Masking

Double Blind

212 participants in 4 patient groups

MINDSpeed Intervention
Experimental group
Description:
Consumption of foods high in polyphenols (i.e., MIND foods) AND speed of processing training
Treatment:
Behavioral: MIND foods
Behavioral: Speed of processing training
MIND food and training control
Active Comparator group
Description:
Consumption of foods high in polyphenols (i.e., MIND foods) AND online (inert) games
Treatment:
Behavioral: MIND foods
Behavioral: Cognitive training control
Control foods and speed of processing training
Active Comparator group
Description:
Consumption of low polyphenol foods AND speed of processing training
Treatment:
Behavioral: Speed of processing training
Behavioral: Control foods
Double Control
Sham Comparator group
Description:
Consumption of low polyphenol foods AND online (inert) games
Treatment:
Behavioral: Control foods
Behavioral: Cognitive training control

Trial documents
1

Trial contacts and locations

1

Loading...

Central trial contact

Daniel Clark, PHD; Lyndsi Moser, BA, CCRP

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2025 Veeva Systems