Mineral Nano Pathology (MINAPUIH)

Civil Hospices of Lyon

Status: Completed

Conditions: Arthroplasty

Treatments: Procedure: hip prosthesis removed metal/metal; Procedure: hip prosthesis removed ceramic/ polyethylene, double mobility; Procedure: hip prosthesis removed metal / polyethylene, double mobility; Procedure: Primary implanted hip prosthesis; Procedure: hip prosthesis removed metal / polyethylene, simple mobility; Procedure: hip prosthesis removed ceramic/ polyethylene, simple mobility; Procedure: hip prosthesis removed ceramic/ceramic

Study type: Observational

Funder types: Other

Identifiers

NCT03898531

2018-A03343-52 (Other Identifier)

69HCL18_0623

Details and patient eligibility

About

Hip arthroplasty is a treatment widely used in most inflammatory, traumatic and degenerative conditions of this joint. The longevity of implants may be disappointing in some cases, despite the promising results obtained during in vitro simulations. Early loco-regional or systemic dissemination, known since the 1990s, of wear particles from these prosthesis may reduce their life span.

The analysis of the particles in the synovial fluid and in the articular tissues by electron microscopy after digestion or directly by optical microscopy, will improve the knowledge on the mechanisms of wear.

This category 3 study is based on the case-control model and will be conducted in a national reference center (hospital la Croix-Rousse- Lyon). It will include a population of adult patients.

Enrollment: 55 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patient,
• Patient including French,
• Patient witness: to be hospitalized in the orthopedic department of the Croix-Rousse hospital for a first hip prosthesis
• Patient test: to be hospitalized in the orthopedic department of the Croix-Rousse hospital for the removal of a hip prosthesis

Exclusion criteria

• Patient protected by law (guardianship, curatorship, safeguard of justice).
• Pregnant or lactating woman
• Patient with suspicion of infection on prosthesis
• Patient opposing his participation in the study

Trial design

55 participants in 7 patient groups

hip prosthesis metal/polyethylene in simple mobility

Treatment:

Procedure: hip prosthesis removed metal / polyethylene, simple mobility

hip prosthesis metal/polyethylene in double mobility

Treatment:

Procedure: hip prosthesis removed metal / polyethylene, double mobility

hip prosthesis ceramic/polyethylene in simple mobility

Treatment:

Procedure: hip prosthesis removed ceramic/ polyethylene, simple mobility

hip prosthesis ceramic/polyethylene in double mobility

Treatment:

Procedure: hip prosthesis removed ceramic/ polyethylene, double mobility

Primary implanted hip prosthesis

Treatment:

Procedure: Primary implanted hip prosthesis

metal / metal prosthesis removed

Treatment:

Procedure: hip prosthesis removed metal/metal

ceramic / ceramic prosthesis removed

Treatment:

Procedure: hip prosthesis removed ceramic/ceramic