Mini-fluid Challenge in Predicting Fluid Responsiveness During Prone Position Spine Surgery

National Taiwan University

Status: Completed

Conditions: Anesthesia

Treatments: Other: Mini-fluid challenge

Study type: Interventional

Funder types: Other

Identifiers

NCT03089710

201612021RIND

Details and patient eligibility

About

Perioperative fluid management is crucial for patients' outcome. Muller et al developed a "Mini-fluid challenge method " to predict fluid responsiveness and the efficacy. The investigators design the study to investigate the effectiveness of mini-fluid challenge test in prone position surgery.

Full description

Perioperative fluid management is crucial for patients' outcome. Series of studies have indicated that adequate fluid management optimizes the cardiac out put, improves tissue perfusion, thus decrease the risk of postoperative morbidity. Muller et al developed a "Mini-fluid challenge method " to predict fluid responsiveness and the efficacy. To the best of our knowledge, the efficacy of the test was not discussed in the perioperative care in prone position surgery. The investigators design the study to investigate the effectiveness of mini-fluid challenge test in prone position surgery.

Enrollment: 100 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: meet both of

1. Patients receiving scheduled prone position spine surgery
2. BMI 18.5~30 kg.m-2

Exclusion Criteria:

1. age younger then 20 yrs or elder than 80 yrs
2. pregnant women
3. patients in intensive care units
4. patients with the underlying disease including respiratory failure(FEV1/FVC < 70 % and FEV1 < 50%), heart failure(NYHA score =III、IV), kidney failure(eGFR< 60 ml.min-1.1.73m-2), liver failure
5. patients with ongoing infection
6. patients allergic to voluven

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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100 participants in 1 patient group

Mini-Fluid Challenge arm

Experimental group

Description:

Fluid challenge test will be presented after induction of anesthesia at a steady state. Fluid challenge test includes 2 components: 100 ml colloid infusion in 1 min followed by 400 ml colloid infusion in 14 mins. Hemodynamic parameter after 1 minute of the end of the 1st and 2nd colloid infusion bolus will be collected. Applied colloid: hydroxyethyl starch

Treatment:

Other: Mini-fluid challenge