Minimally Invasive Biomarker for Asthma Disease Severity

Mayo Clinic

Status: Completed

Conditions: Healthy; Asthma

Study type: Observational

Funder types: Other

Identifiers

NCT02225678

14-001168

Details and patient eligibility

About

Can a clinical test be developed that could help manage asthma symptoms?

Full description

Project goals:

Develop a point-of-service assay to assess eosinophilic airway inflammation

Proposal Specific Aims:

1. To establish the infrastructure and test the feasibility of sputum collection in a clinical setting as a minimally invasive patient sampling process for biomarker testing
2. To transform the laboratory-based eosinophil peroxidase (EPX) ELISA detection assay into a clinic-friendly assessment that does not require sophisticated laboratory equipment

Enrollment: 25 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Asthma subjects:

Inclusion

• Provider diagnosed asthma
• FeNO>50 ppb
• FEV1 > 1.0 Liter

Exclusion

• COPD by history
• Bronchiectasis by history
• Pregnant participants

Normal subjects:

Inclusion

• Age matched to asthma subjects

Exclusion

• Any eosinophil disorder by history
• Asthma by history
• Rhinitis or sinusitis by history