Minipuberty in Infants Born With Potential Hypogonadism Hypogonadotrope (MiniNO)

Vaud University Hospital Center

Status: Enrolling

Conditions: CHH; DSD

Study type: Observational

Funder types: Other

Identifiers

NCT05058781

CER-VD 2016-01232

Details and patient eligibility

About

Disorders of sex development (DSD) occur in 1/3000 births and are defined by variation in aspect of external genital organs, e.g. cryptorchidism, hypospadias and micropenis in male infants and clitoral hypertrophy in female infants. Genetic, hormonal and environmental factors are implicated in DSD. Infants with congenital hypogonadism hypogonadotrope (CHH) can present with DSD. Evaluation of hormonal profile during minipuberty could be of great help to better characterize the etiology of DSD and CHH in particular. Our main objective is to study hormonal profile during the minipuberty of infants born with DSD or born from parents with CHH compared to controls.

Enrollment: 100 estimated patients

Sex: All

Ages: Under 9 months old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• infants born with symptoms of DSD
• infants born from parents with CHH

Exclusion criteria

• premature < 35 weeks of gestation
• male infants with high scrotal cryptorchidism