Minocycline to Reduce Pain After Carpal Tunnel Release

VA Palo Alto Health Care System

Status and phase: Completed; Phase 2

Conditions: Post-operative Pain; Chronic Pain

Treatments: Drug: Minocycline; Drug: placebo

Study type: Interventional

Funder types: Other; Other U.S. Federal agency

Identifiers

NCT02051296

RX000487

Details and patient eligibility

About

The investigators are looking at whether peri-operative minocycline will reduce the duration of pain after minor hand surgery: carpal tunnel release and trigger finger release.

The investigators' hypothesis is that minocycline will reduce post-operative pain.

Full description

This is a double blinded randomized controlled trial. Patients are given 100mg of minocycline 2 hours prior to their procedure and then 100mg two times a day for 5 days. The subjects are then contacted daily to check their level of pain. The investigators' outcome of interest is time to pain resolution.

The investigators will perform a futility analysis to assess if a larger trial would be a reasonable next step after this pilot study.

Enrollment: 131 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adult, Veteran,

Exclusion criteria

• Kidney failure, Liver failure, thrombocytopenia, ALS, SLE, Frailty, unable to understand survery

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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131 participants in 2 patient groups, including a placebo group

minocycline

Experimental group

Description:

perioperative minocycline for 5 days, starting 2 hours prior to surgery then 100mg BID

Treatment:

Drug: Minocycline

Placebo

Placebo Comparator group

Description:

PLacebo

Treatment:

Drug: placebo