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Minor Histocompatibility Vaccination After Allogeneic Stem Cell Transplantation for Advanced Hematologic Malignancies

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The University of Chicago

Status and phase

Terminated
Phase 1

Conditions

Graft Versus Host Disease
Myeloproliferative Disorders
Lymphoma
Myeloma
Preleukemia

Treatments

Drug: Fludarabine
Drug: Melphalan
Drug: Campath

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

This is a clinical research study designed to evaluate whether the administration of a vaccine to patients after transplant consisting of a minor histocompatibility antigen (mHag peptide) mixed with G-CSF (a drug intended to stimulate the immune system) can stimulate increased graft versus leukemia (GVL) responses without causing graft-versus-host disease (GVHD).

Enrollment

1 patient

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Relapsed or refractory acute myelogenous or lymphoid leukemia.
  • Acute myeloid or lymphocytic leukemia in first remission at high-risk for recurrence.
  • Chronic myelogenous leukemia in accelerated phase or blast-crisis.
  • Chronic myelogenous leukemia in second or subsequent chronic phase
  • Recurrent or refractory malignant lymphoma or Hodgkin's disease
  • Multiple myeloma at high risk for disease recurrence.
  • Chronic lymphocytic leukemia, relapsed or with poor prognostic features.
  • Myeloproliferative disorder (polycythemia vera, myelofibrosis) with poor prognostic features.

Exclusion criteria

  • Clinical progression.
  • Contra-indications for vaccination.

Trial design

Primary purpose

Treatment

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

1 participants in 1 patient group

Vaccine
Experimental group
Treatment:
Drug: Campath
Drug: Melphalan
Drug: Fludarabine

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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