miRNA in Chronic Kidney Diseases

Josip Juraj Strossmayer University of Osijek

Status: Not yet enrolling

Conditions: Chronic Kidney Diseases

Study type: Observational

Funder types: Other

Identifiers

NCT06316284

miRNA-CKD

Details and patient eligibility

About

Oxidative stress and endoplasmic reticulum (ER) stress play a key role in tubular damage in both acute kidney injury and chronic kidney disease (CKD). Oxidative stress in the kidneys promotes renal vascular remodeling and increases preglomerular resistance. These are key elements in hypertension, acute and chronic kidney injury, as well as diabetic nephropathy. Chronic renal hypoxia is highlighted as the final common pathway to end-stage renal disease (ESRD). MicroRNA molecules (miRNA) also play an important role in these processes. MicroRNAs (miRNAs) are regulators of gene expression and play a role in the progression of renal ischemia-reperfusion injury. Although the pathophysiological contribution of microRNAs (miRNAs) to kidney damage has also been highlighted, the effect of miRNAs on kidney damage under conditions of oxidative and ER stress remains understudied.

Enrollment: 90 estimated patients

Sex: All

Ages: 18 to 69 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy normotensive adults (eGFR CKD-EPI >90 mL/min/1.73 m2, BP <140/90 mmHg)
• hypertensive adults (eGFR CKD-EPI >90 mL/min/1.73 m2, BP >140/90 mmHg)
• patients with chronic kidney disease stage 3-5 (eGFR CKD-EPI< 60 mL/min/1.73 m2)

Exclusion criteria

• cardiovascular diseases, but hypertension
• diabetes
• cerebrovascular diseases
• peripheral artery disease

Trial design

90 participants in 3 patient groups

Chronic kidney disease group

Description:

Patients with stage 3-5 CKD (eGFR CKD-EPI \<60 mL/min/1.73 m2)

Healthy controls

Description:

Healthy normotensive patients (eGFR CKD-EPI \>90 mL/min/1.73 m2, BP \<140/90 mmHg)

Hypertensive Group

Description:

Hypertensive patients without CKD (eGFR CKD-EPI \>90 mL/min/1.73 m2, BP \>140/90 mmHg)