miRNA in Pediatric Gastritis (microRNA)

Benha University

Status

Not yet enrolling

Conditions

HELICOBACTER PYLORI INFECTIONS

Treatments

Diagnostic Test: miRNA gene expression

Study type

Interventional

Funder types

Other

Identifiers

NCT07300787

MD 5-10-2023

Details and patient eligibility

About

The goal of this clinical trial is to assess the differential expression of miR-155 and miRNA-204 in relation to gastritis, and assess their relation with the presence of H. pylori in children.

Full description

patients will be subjected to full history taking including age, sex, residence, present illness; onset, course and duration, abdominal pain, other associated symptoms and family history. Assessment of anthropometric measurement Patients' height and weight for age and BMI percentiles were checked according to Egyptian growth curves (9).

Abdominal Ultrasonography upper GITendoscopy mi RNAGene expression was done by quantitative reverse transcription-polymerase chain reaction (qRT-PCR).

Enrollment

100 estimated patients

Sex

All

Ages

1 to 18 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

recurrent abdominal pain warranting upper gastrointestinal endoscopy or gastroscopy including

peptic-like dyspepsia (identified by two or more symptoms such as periodic pain, pain relief with food or antacid, pre-meal or hunger-induced pain, nausea/vomiting, and nighttime pain),
dysmotility-like dyspepsia (characterized by abdominal distension, anorexia, weight loss, pain worsening with food/milk, and belching),
and reflux-like dyspepsia (manifesting as heartburn, chest pain

Exclusion criteria

-patients with gastrointestinal disorders explaining abdominal pain (e.g., inflammatory bowel disease, celiac disease, functional abdominal pain)

, -patients on proton pump inhibitors, as well as those with significant medical comorbidities.

Exclusion Criteria:

Trial design

Primary purpose

Diagnostic

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

100 participants in 2 patient groups, including a placebo group

Gastritis group

Active Comparator group

Description:

All included patients were subjected to full history taking including age, sex, residence, present illness; onset, course and duration, abdominal pain, other associated symptoms and family history. Assessment of anthropometric measurement Patients' height and weight for age and BMI percentiles were checked according to Egyptian growth curves . Abdominal Ultrasonography upper GIT ENDOSCOPY miRNA gene expression

Treatment:

Diagnostic Test: miRNA gene expression

Control healthy group

Placebo Comparator group

Description:

miRNA gene expression

Treatment:

Diagnostic Test: miRNA gene expression