miRNA in Sweat, a Novel Digital Biomarker for Detection of Active Tuberculosis (TB)

University Hospital Basel

Status: Withdrawn

Conditions: Active Tuberculosis

Treatments: Diagnostic Test: Next Generation Sequencing

Study type: Observational

Funder types: Other

Identifiers

NCT05048381

2021-01810 am21Eckstein2;

Details and patient eligibility

About

The detection of miRNA (non-coding ribonucleic acid) in the blood in the context of active tuberculosis is an innovative approach to the detection of new disease-specific biomarkers.

The primary goal of this analysis is to define, for the first time, an miRNA fingerprint for tuberculosis in sweat. Samples that were collected as part of the Sweatb Study (NCT03667742) project are examined for the occurrence of disease-specific, non-coding miRNAs to define new biomarkers in the sweat. These biomarkers can be detected non-invasively and will help in the detection of patients with active tuberculosis.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients
• Ability to understand the purpose of the study, provide signed and dated informed consent by patient or his/her legal representative
• In-patients with acute tuberculosis, suspected tuberculosis or other pulmonary diseases (pneumonia, Bronchitis, COPD)

Inclusion criteria Healthy Donors:

• negative for Quantiferon- TB Gold Plus Test or ELISpot

Exclusion criteria

• Written rejection of the consent for the further use of the data