miRNA (microRNA) and FGF21 (Fibroblast Growth Factor-21) Profile in First Trimester and Gestational Diabetes Prediction

Chiang Mai University

Status: Active, not recruiting

Conditions: Gestational Diabetes

Treatments: Other: blood draw

Study type: Observational

Funder types: Other

Identifiers

NCT05632055

OBG-2563-07494

Details and patient eligibility

About

The goal of this observational study is to compare miRNA and FGF21 in pregnancy with and without GDM (Gestational Diabetes) The main question it aims to answer that miRNA and FGF21 are different between two groups.

Participants will be retrieved blood sample during first trimester and undergone 100 gm OGTT (oral glucose challenge test) during 24-28 weeks of gestation.

Full description

Pregnant women who attended antenatal care at Maharaj Nakorn Chiang Mai hospital during first trimester were recruited.

Participants received routine standard prenatal care except,

1. additional blood test during 11-13 week 6 days (Blood was collected for further analysis)
2. performed 75gm OGTT during 24-28 week

Baseline data and pregnancy outcome were reviewed.

Enrollment: 160 patients

Sex: Female

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• singleton pregnant women who attend at our clinic in first trimester

Exclusion criteria

• known underlying disease such as chronic hypertension, pregestational diabetes, SLE
• normal structural fetal anatomical screening
• incomplete obstetric data

Trial design

160 participants in 2 patient groups

Pregnancy with GDM

Description:

Pregnant women who positive test for 100gm OGTT (abnormal 2 or more blood glucose level according NDDG (National Diabetes Data Group) criteria)

Treatment:

Other: blood draw

Pregnancy without GDM

Description:

Pregnant women who negative test for 100gm OGTT

Treatment:

Other: blood draw