MiRNAs Evaluate the Prognosis of Sepsis (METPS)

Chinese PLA General Hospital (301 Hospital)

Status: Unknown

Conditions: Sepsis

Study type: Observational

Funder types: Other

Identifiers

NCT01207531

301PLAGH-2010915

Details and patient eligibility

About

Sepsis is a common cause of death in intensive care unit, timely and accurate diagnosis and treatment directly affect the survival rate. MiRNA is a post-transcriptional small RNA which regulate mRNA expression. The present study was designed to screen several miRNA by microarray which evaluate the sepsis prognosis in order to be a new target for the treatment of sepsis.

Full description

The study is a non-intervention, prospective observational study. Purpose of this sudy is to screening several miRNAs by microarray which can evaluate the prognosis of sepsis . We will collect serum samples from patients with sepsis in SICU, RICU and EICU of 301 Hospital since September 2009 , and then use the chip and qRT-PCR to Screen miRNAs which can evaluate the prognosis of sepsis, and statistical analysis the miRNAS expression correlation with SOFA score.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of sepsis
• Patients who agree with the study

Exclusion criteria

• Aged <18 years;
• Into the group who died within 24 hours;
• Agranulocytosis (<0.5 × 109 / L);
• Combined HIV infection.

Trial design

100 participants in 2 patient groups

Survival Group

Death group