Misopristol Versus Pitocin for Second Trimester Abortion

Hadassah Medical Center

Status and phase: Completed; Phase 4

Conditions: Abortion, Missed

Treatments: Drug: mifepristone and oxytocin; Drug: mifepristone and misopristol

Study type: Interventional

Funder types: Other

Identifiers

NCT00784797

PitocinPGMyf-HMO-CTIL

Details and patient eligibility

About

Second trimester abortion can be done surgically or medically. Medical abortion with mifepristone and misopristol is one of the common protocol, but misopristol have high rate side effect. The investigators recent study proved the efficacy of pitocin after mifepristone in second trimester abortion with minimal side effects.

Working hypothesis and aims: To compare misopristol and pitocin after mifepristone preparation in second trimester in seccess rate, interval to abortion, side effects and patient satisfaction.

Enrollment: 145 patients

Sex: Female

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• midtrimester late abortion
• midtrimester induced abortion

Exclusion criteria

• placenta previa
• infected abortion
• rupture of membranes
• s/p cesarean section *2 or more

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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145 participants in 2 patient groups

pitocin

Active Comparator group

Description:

high dose pitocin drip 48 hours after mifepristone preparation.

Treatment:

Drug: mifepristone and oxytocin

misopristol

Active Comparator group

Description:

vaginal and oral misopristol 48 hours after mifepristone preparation.

Treatment:

Drug: mifepristone and misopristol