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Misoprostol for Second Trimester Pregnancy Termination (MIS)

A

Assiut University

Status and phase

Completed
Phase 2

Conditions

Intra Uterine Fetal Death

Treatments

Procedure: termination of second trimester pregnancy

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

The majority of second-trimester pregnancy termination performed in the United States are performed surgically by dilation and evacuation. The frequency of induction of abortion increases as gestational age advances. In the late second trimester and early third trimester, induction is the primary method of termination in cases of fetal abnormalities. In many other countries, however, induction is the primary method of abortion throughout the second trimester

Enrollment

180 patients

Sex

Female

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

  • Pregnancy 13-24 weeks.
  • Women with indication for termination of the pregnancy due to intra uterine fetal death

Exclusion Criteria:-Pregnancy before 13 weeks.

  • Pregnancy beyond 24 weeks.
  • Women with scared uterus.
  • Known hypersensitivity for misoprostol.
  • Refusal of the woman to participate.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

180 participants in 2 patient groups

extra amniotic misoprostol
Experimental group
Description:
misoprostol dissolved in warm saline , become dissolute misoprostol saline solution(200 microgram every 4 hours)
Treatment:
Procedure: termination of second trimester pregnancy
vaginal misoprostol
Experimental group
Description:
misoprostol tablet soaked with distilled water and inserted in the posterior fornix of the vagina( 200 microgram every 4 hours)
Treatment:
Procedure: termination of second trimester pregnancy

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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