Misoprostol for Second Trimester Pregnancy Termination (MIS)

Assiut University

Status and phase: Completed; Phase 2

Conditions: Intra Uterine Fetal Death

Treatments: Procedure: termination of second trimester pregnancy

Study type: Interventional

Funder types: Other

Identifiers

NCT02669420

220

Details and patient eligibility

About

The majority of second-trimester pregnancy termination performed in the United States are performed surgically by dilation and evacuation. The frequency of induction of abortion increases as gestational age advances. In the late second trimester and early third trimester, induction is the primary method of termination in cases of fetal abnormalities. In many other countries, however, induction is the primary method of abortion throughout the second trimester

Enrollment: 180 patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Pregnancy 13-24 weeks.
• Women with indication for termination of the pregnancy due to intra uterine fetal death

Exclusion Criteria:-Pregnancy before 13 weeks.

• Pregnancy beyond 24 weeks.
• Women with scared uterus.
• Known hypersensitivity for misoprostol.
• Refusal of the woman to participate.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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180 participants in 2 patient groups

extra amniotic misoprostol

Experimental group

Description:

misoprostol dissolved in warm saline , become dissolute misoprostol saline solution(200 microgram every 4 hours)

Treatment:

Procedure: termination of second trimester pregnancy

vaginal misoprostol

Experimental group

Description:

misoprostol tablet soaked with distilled water and inserted in the posterior fornix of the vagina( 200 microgram every 4 hours)

Treatment:

Procedure: termination of second trimester pregnancy