Misoprostol for Second Trimester Termination of Pregnancy

Ataturk University

Status and phase: Completed; Phase 3

Conditions: Abortion, Induced

Treatments: Drug: Vaginal misoprostol; Drug: Buccal misoprostol

Study type: Interventional

Funder types: Other

Identifiers

NCT02048098

atauni9

Details and patient eligibility

About

The purpose of this study is to compare the efficacy of 400 µg vaginal misoprostol per 3 hours to 400 µg buccal misoprostol per 3 hours in second trimester termination of viable pregnancy

Enrollment: 130 patients

Sex: Female

Ages: 16 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• gestational age between 12-24 weeks
• live fetus
• singleton pregnancy
• Bishop score <5
• no uterine contraction

Exclusion criteria

• prostaglandin allergy
• a scar in uterus
• uterine abnormality
• premature rupture of membranes

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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130 participants in 2 patient groups

Buccal misoprostol

Active Comparator group

Description:

400 µg buccal misoprostol per 3 hours

Treatment:

Drug: Buccal misoprostol

vaginal misoprostol

Active Comparator group

Description:

400 µg vaginal misoprostol per 3 hours

Treatment:

Drug: Vaginal misoprostol