Misoprostol in the Treatment of Postpartum Hemorrhage

Gynuity Health Projects

Status

Completed

Conditions

Postpartum Hemorrhage

Treatments

Drug: Misoprostol

Study type

Interventional

Funder types

Other

Identifiers

NCT00116480

2.4.2

Details and patient eligibility

About

Postpartum haemorrhage (PPH) remains a leading cause of maternal mortality, despite treatment with conventional methods. Uncontrolled reports and three small randomised controlled trials have suggested that misoprostol may have an additive effect to routine treatment, and there is a serious danger that this method will be used widely without research to document the effectiveness or risks of this method. In this randomised controlled trial (RCT), we propose to test whether 600 μg of sublingually administered misoprostol in women requiring additional uterotonics after delivery, and after routine syntocinon to all women during or after delivery, has additional effects above the additional conventional uterotonics in reducing PPH. Women with measured blood loss greater than or equal to 500 mls in 4 Karachi hospitals who give consent will be given locally routine treatment for PPH. In addition, they will be enrolled by drawing the next of a series of randomised treatment packs containing misoprostol or placebo. The primary outcome measure will be blood loss greater than or equal to 500 mls after enrolment.

Enrollment

61 patients

Sex

Female

Volunteers

No Healthy Volunteers

Inclusion criteria

All women delivering vaginally with clinically diagnosed PPH requiring uterotonics

Exclusion criteria

Refusal to give consent for participation or if the woman is too distressed to give consent
Woman is not entitled to give informed consent (e.g. minors without a guardian)
Woman who had a caesarean section
Delivery is regarded as abortion (gestational age < 28 weeks)