Misoprostol Versus Active Management of Labour in CS

Aljazeera Hospital

Status and phase: Completed; Phase 1

Conditions: Cesarean Section

Treatments: Drug: Syntocinon and using extra uterotonic drugs when needed ; methergine carboprost; Drug: Misoprostol + syntocinon and using extra uterotonic drugs when needed ; methergine

Study type: Interventional

Funder types: Other

Identifiers

NCT03390010

Active management of labour

Details and patient eligibility

About

Several treatment strategies are emplemented to prevent post delivery hemorage and decreasing maternal morbidity and mortality .

Full description

Many approved drugs are used in prophylaxis against postpartum hemorage from these medications are the (syntocinon combined with methergine ) that are known as active management of labour drugs .

Moreover there is misotac , that also guards against postpartum hemorage .

All these medications act in a different way to cause uterine contraction post delivery to prevent uterine atony .

-Here we are comparing the additive value of misotac intrauterine to syntocinon and methergine in comparison to the usually used syntocinon plus methergine .

Enrollment: 300 patients

Sex: Female

Ages: 18 to 42 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• • All patients included in this research were aged 18-42 years, pregnant 37 weeks till 42 weeks

  • no medical disorders with pregnancy e.g DM, HTN. All patients were subjected to full history taking, examination.

Exclusion criteria

• Exclusion Criteria:

  • The following patients were excluded , GA before 37 weeks or after 42 weeks , medical disorders with pregnancy eg. DM with pregnancy, HTN with pregnancy

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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300 participants in 2 patient groups

Extra medication group

Active Comparator group

Description:

-Procedure : Giving misoprostol plus syntocinon during CS this group in which prevention of uterine atony is made by intrauterine misoprostol plus the usual syntocinon and using extra uterotonic drugs when needed ; methergine , carboprost

Treatment:

Drug: Misoprostol + syntocinon and using extra uterotonic drugs when needed ; methergine

Active management of labour group

Active Comparator group

Description:

* Procedure: Giving syntocinon during cesarean section * this group in which prevention of uterine atony is made by the usual active management of labour syntocinon and using extra uterotonic drugs when needed ; methergine , carboprost

Treatment:

Drug: Syntocinon and using extra uterotonic drugs when needed ; methergine carboprost