Misoprostol Versus Uterine Striating by Bladder Filling for Pain Relief During Office Hysteroscopy

Cairo University (CU)

Status and phase: Completed; Phase 2

Conditions: Pain

Treatments: Drug: Misoprostol; Other: Bladder Filling

Study type: Interventional

Funder types: Other

Identifiers

NCT02328495

Misoprostol /bladder/hystero

Details and patient eligibility

About

The aim of this study is to compare the effectiveness of misoprostol versus uterine straightening by bladder filling for pain relief in menopausal patients undergoing office hysteroscopy.

Full description

Several studies revealed that cervical ripening with misoprostol is effective in reducing pain especially in postmenopausal patients. A recent randomized controlled trial revealed that uterine striating by bladder filling prior to office hysteroscopy is associated with reduced pain perception and easier introduction of hysteroscope through the cervix.

The aim of this study is to compare the effectiveness of misoprostol versus uterine straightening by bladder filling for pain relief in menopausal patients undergoing office hysteroscopy.

Enrollment: 76 patients

Sex: Female

Ages: 40 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Menopausal patients who have an indication for office hysteroscopy

Exclusion criteria

• Nulliparous patients, patients with cervical pathology and previous cesarean section or cervical surgery.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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76 participants in 2 patient groups

Misoprostol

Active Comparator group

Description:

Misoprostol (400µg) is administered vaginally 12 hours before office hysteroscopy

Treatment:

Drug: Misoprostol

bladder Filling

Active Comparator group

Description:

Uterine straightening by bladder filling before office hysteroscopy

Treatment:

Other: Bladder Filling