Mitochondrial Dysfunction and Oxidative Stress in Chronic Obstructive Pulmonary Disease (COPD) Patients

5 Santé

Status: Completed

Conditions: COPD Patients

Treatments: Other: Training

Study type: Interventional

Funder types: Other

Identifiers

NCT01183052

2009-A00426-51

Details and patient eligibility

About

The purpose of this study is to understand the underlying mechanisms of improved exercise tolerance in COPD patients after training program.

Full description

Training protocol used is based on recommendations (Nici et al., 2006) and was previously used in our group (Varray et al., 1991; Vallet et al., 1997). A minimum of 20 sessions in 4-6 weeks were proposed. The exercise intensity of exercise corresponds to target heart rate at ventilatory threshold measured during incremental exercise test. Training at this intensity allowed us to individualize effort for each patient.

Enrollment: 30 patients

Sex: All

Ages: 50 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Sedentary mild to severe COPD patients

Exclusion criteria

• Neuromuscular disease
• Chronic heart failure
• Renal diseases
• Liver diseases
• Obesity

Trial design

30 participants in 1 patient group

Training

Other group

Description:

20 sessions of training

Treatment:

Other: Training