Mitochondrial Metabolism and Hepatic Complications of Obesity (DMSO)

Nantes University Hospital (NUH)

Status: Withdrawn

Conditions: Obesity

Treatments: Other: liver biopsy

Study type: Interventional

Funder types: Other

Identifiers

NCT03302481

RC17_0055

Details and patient eligibility

About

The study aims to characterize mitochondrial metabolism in the liver of obesity surgery patients and to study its relationships with hepatic steatosis, inflammation, and fibrosis.

Full description

The study aims to characterize mitochondrial metabolism in the liver of obesity surgery patients and to study its relationships with hepatic steatosis, inflammation, and fibrosis. The protocols involves a per-operative hepatic needle biopsy for mitochondria characterization and histological scoring of steatosis, inflammation, and fibrosis

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adult men and women
• affiliated to a social security
• candidate for laparoscopic obesity surgery

Exclusion criteria

• Excessive alcohol consumption:> 20 g / day (woman),> 30 g / day (male)
• Chronic viral hepatitis B or C
• Genetic hemochromatosis
• Taking the following drugs for at least 3 months up to 6 months before the scheduled date of obesity surgery: systemic corticosteroids, amiodarone, methotrexate
• Wilson's disease
• autoimmune hepatitis
• alpha 1-antitrypsin deficiency
• abetalipoproteinemia
• Contraindications to liver biopsy

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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0 participants in 1 patient group

Experimental Group

Experimental group

Description:

the biopsies will be performed under laparoscopy and taken in the lower part of the right hepatic lobe

Treatment:

Other: liver biopsy